What is the difference between a releasing and a minimum effective vaccine titre?

The releasing titre is the minimum titre required in the final product before it can be released by the manufacturer’s Quality Control department, and is primarily dependent on the required potency and secondarily dependent on the rate of decay of live viruses in the vaccine, as indicated by stability tests.

The minimum effective vaccine titre is the lowest vaccine titre for which efficacy in the target species has been convincingly demonstrated (survival after challenge infection of a defined number of vaccinated animals – for more information, see here).

Sometimes these two titres differ because in some countries a ‘safety margin’ has been incorporated due to the loss of infectivity when baits are distributed in the field and exposed to the prevailing climatic conditions before they are consumed by the animals.


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Version 1 - Last updated November 2012